Abstract
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.
Highlights
In the search for a logical and rational methodology for vaccine development, we have proposed that in-depth, chemical, physical, structural and even mathematical approaches associated with an understanding of molecules’ biological functions
We have previously shown that immune protection-inducing protein structures (IMPIPS) (Patarroyo et al, 2015a) have a polyproline type II, left-handed-like (PPIIL-like) structure to enable fitting into the appropriate HLA-DRβ1∗ peptide binding region (PBR) (Patarroyo et al, 2012a, 2015a)
Our group found that a specific group of immune protectioninducing protein structure (IMPIPS, involving LLPI and short-lived protective immunity (SPI)) had or contained PPIIL-like structures in our search for a logical and rational methodology for malaria vaccine development (Patarroyo et al, 2012a,b, 2015a)
Summary
In the search for a logical and rational methodology for vaccine development, we have proposed that in-depth, chemical, physical, structural and even mathematical approaches associated with an understanding of molecules’ biological functions. We have previously shown that immune protection-inducing protein structures (IMPIPS) (Patarroyo et al, 2015a) have a polyproline type II, left-handed-like (PPIIL-like) structure to enable fitting into the appropriate HLA-DRβ1∗ peptide binding region (PBR) (Patarroyo et al, 2012a, 2015a).
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