Abstract
Introduction: Due to advance in medical and surgical management nosocomial fungal infection rate has been increased. Recently Candididiasis has become one of the major fungal infections among hospitalized patients. Several Candida species can give rise to same clinical presentations but their antifungal susceptibility patterns may be different. The aim of the study is species identified of Candida, isolated from different clinical samples and to carry out their in vitro antifungal susceptibility tests. Methods: From different clinical samples several Candida species were isolated. Speciation of Candida was done by using Corn meal agar, Chrom agar and Hi-Candida identification kit. In vitro antifungal susceptibility to fluconazole, ketoconazole and amphotericin B was performed by disc diffusion method as per CLSI document M44A. Results: From 108 samples, most common species isolated was C. albicans (42.5%), followed by C. tropicalis, C. glabrata, C. parapsilosis and C. krusei. Overall 71.87% of isolates were found to be fluconazole sensitive. Fluconazole resistant rate is seen higher in Candida krusei, Candida glabrata, and Candida tropicalis. Ketoconazole was found to be sensitive against 87% of isolates. Amphotericin B was effective against 100% of isolates, although reduced zone size to Amphotericin B was seen by 10 isolates. Conclusion: Speciation of Candida and antifungal susceptibility testing should be done routinely to prevent therapeutic failures.
Published Version
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