Species Distribution and Antifungal Susceptibility Pattern of Candiduria in a Tertiary Care Hospital of Western Uttar Pradesh

Abstract

Background: Urinary tract infection (UTI) is one the most common infections encountered in clinical practice.Bacteria and fungus are the common microorganisms associated with UTI. This study was carried out with the aimto identify the species distribution and anti-fungal susceptibility pattern of candiduria in a tertiary care Hospitalof Western Uttar Pradesh.Methods: This prospective hospital-based study was conducted over a period of one year. A total of 6250 urinesamples were subjected for isolation and identification of microorganisms as per standard microbiological method.The antifungal susceptibility testing was performed for fungal isolates as per Clinical and Laboratory StandardsInstitute (CLSI) M44-A document recommendations.Result: The culture positivity rate was 58.43%. Among the culture positive, Candida species was isolated from141(3.86%). There was predominanceof Non-albicans candida(NAC) species 131 (92.91%) as compared to Candidaalbicans 10(7.09%). The positivity was more in the females in the age group of >60 years. C. tropicalis, was thepredominant NAC species isolated. The isolates showed good susceptibility towards azoles such as fluconazoleand voriconazole. However, high level of resistance was seen towards clotriomazole.Conclusion: Predominance of NAC species in cases of candiduriaand emerging resistance towards azoles over theyears is a matter of concern. Knowledge regarding the species distribution and its antifungal susceptibility testswill help the clinicians in empirical therapy for better patient outcome.