Abstract
A novel analytical method based on centrifuging dispersive liquid-liquid microextraction (CD-LLME) procedure for pre-concentration of As (III) has been developed prior to determine by hydride generation atomic absorption spectrometry (HG-AAS). In this method, 0.1 g of a task-specific ionic liquids (methyltrioctylammonium 2-mercaptobenzoate; TOMAS; TSIL) as the extracting and complexing solvent and acetone as dispersant solvent were rapidly added into the water and blood samples at pH 4.5. The As (V) is simply calculated by difference between total concentration and inorganic forms As (III) in liquid samples. By optimizing parameters, the enrichment factor (EF) was obtained 9.8 and 49.6 for blood and water samples, respectively. The limit of detection (LOD) of 22.4 ngL-1 and 4.3 ngL-1 were achieved for 10 mL and 50 mL of As(III) in blood and water samples, respectively (RSD<%5). The real samples were validated by certified reference material (CRM) by proposed procedure.
Highlights
Analytical methods has important role for determining hazardous heavy metal in different matrixes such as human blood and environmental samples
Analytical methods based on nanotechnology and ionic liquids was used for determination arsenic concentration in the blood, urine and serum samples by different instruments such as inductively coupled plasma mass spectrometry (ICP-MS), electro-thermal atomic absorption spectrometry (ET-AAS) and hydride generation atomic absorption spectrometry (HG-AAS) [1]
The liquid–liquid extraction (LLE)[15], cluod point extraction (IL-Cloud point extraction (CPE))[16], ionic liquid based on solid phase extraction (IL-SPE) [17] was reported by previous papers
Summary
Analytical methods has important role for determining hazardous heavy metal in different matrixes such as human blood and environmental samples. Analytical methods based on nanotechnology and ionic liquids was used for determination arsenic concentration in the blood, urine and serum samples by different instruments such as ICP-MS, ET-AAS and HG-AAS [1]. Inorganic arsenic compounds are toxic in human body but organic arsenic is usually less harmful [2]. Speciation and determination of arsenic in human blood and water samples is very important [3]. The toxicity of arsenic compounds is generally linked to the soluble inorganic trivalent forms, which is controlled by pH. Normal arsenic concentrations in blood and urine are typically below 50 μg L−1 and 7 μg L−1, respectively [4].
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