Abstract
Over the past 40 years, studies on tooth regeneration have been conducted. These studies comprised two main flows: some focused on epithelial–mesenchymal interaction in the odontogenic region, whereas others focused on creating a supernumerary tooth in the non-odontogenic region. Recently, the scope of the research has moved from conventional gene modification and molecular therapy to genome and transcriptome sequencing analyses. However, these sequencing data have been produced only in the odontogenic region. We provide RNA-Seq data of not only the odontogenic region but also the non-odontogenic region, which loses tooth-forming capacity during development and remains a rudiment. Sequencing data were collected from mouse embryos at three different stages of tooth development. These data will expand our understanding of tooth development and will help in designing developmental and regenerative studies from a new perspective.
Highlights
Transcriptome Analysis of Edentulous and Dental Region the epithelium and mesenchyme in tooth development was published (Jernvall and Thesleff, 2000), regeneration research of the tooth-forming region has been based on the first flow
The scope of tooth regeneration research has moved from conventional gene modification and molecular therapy in vitro and in vivo to an approach through genome and transcriptome analyses
RNA was extracted from the diastema and molar regions by stage, and all sample gatherings were repeated with three biological replicates
Summary
Transcriptome Analysis of Edentulous and Dental Region the epithelium and mesenchyme in tooth development was published (Jernvall and Thesleff, 2000), regeneration research of the tooth-forming region has been based on the first flow. Several transcriptome analyses of tooth germ development and tissues in permanent growing incisors of rodents have been published within the last 5 years (Seidel et al, 2017; Yang et al, 2017; Sharir et al, 2019; Chiba et al, 2020; Krivanek et al, 2020; Hallikas et al, 2021). These next-generation sequencing (NGS) studies for tooth development are focused on epithelial–mesenchymal interactions and stem cell biology. The presented RNA-Seq results are the first datasets describing odontogenic and non-odontogenic regions of mouse embryos and provide a fundamental understanding of the spatiotemporal relationship
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