Abstract
The emergence of spatially offset Raman spectroscopy (SORS) permits the application of Raman spectroscopy to deep non-invasive characterization of turbid media. Similar to conventional Raman spectroscopy, SORS allows for a detection technique with excellent chemical selectivity with simple instrumentation, while maintaining the integrity of the sample. SORS takes advantage of the spatial component of the photon migration process by collecting the Raman scattered light at a point that is spatially offset from the incident illumination point, gaining information from subsurface layers of the material. Applications of SORS include disease diagnosis, non-invasive detection of small molecules including glucose and neurotransmitters, chemical analysis of pharmaceuticals, screening techniques for national security, and the study of art preservation.
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