Abstract
Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250 μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2 μg/μl saline; 5 μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS + 6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS + 6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
