Abstract
We investigate a spatial coordinate correction (SCC) method to track motion with high accuracy for optical coherence elastography (OCE). Through SCC, we refer the displacement field tracked by optical coherence tomography (OCT) in the loaded sample to individual material points defined in a fixed coordinate system. SCC allows OCE to perform spatially and temporally unambiguous tracking of displacement and enables accurate mechanical characterization of biological tissue for cancer diagnosis and tumor margin assessment. In this study, we validated the effectiveness of motion tracking based on SCC using experimental OCE data obtained from ex vivo human breast tissues.
Highlights
Knowledge on tissue mechanical properties is highly significant in different fields of biomedicine [1]
spatial coordinate correction (SCC) is needed for optical coherence elastography (OCE) characterization of heterogeneous sample, because the same optical coherence tomography (OCT) pixel sees different material points during the loading process
We described and validated motion tracking based on spatial coordinate correction
Summary
Knowledge on tissue mechanical properties is highly significant in different fields of biomedicine [1]. It has been noted that an OCT pixel in general sees different material points during the process of sample loading in OCE measurement [21,22]. When the same pixel sees a different group of material points and generates OCT signal with small magnitude, the motion tracking results can be highly biased. Accurate assessment of displacement is critical for subsequent analysis of OCE data and there is a strong need for spatially and temporally accurate displacement tracking, to allow unambiguous OCE measurement for effective tissue characterization In this manuscript, we describe a spatial coordinate corrected (SCC) motion tracking method that refers the results of displacement tracking to individual material points defined in a fixed coordinate system. The effectiveness of the SCC motion tracking method was demonstrated using experimental data obtained from compression OCE measurement of ex vivo human breast tissue samples
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