Abstract

In the present study, for the first time, spectral-domain optical coherence tomography (SD-OCT) and optical coherence elastography (OCE) have been used in a combinatorial manner to characterise the corneal limbal architecture and biomechanical properties. 11 cadaveric corneas were obtained from a UK tissue bank. The architecture and effect of donor age on the limbal Palisades of were quantified using SD-OCT. OCE was used to determine the Young’s modulus of the epithelium and POV regions. The regional stiffness differences were observed, with ageing effect. Hence a correlation of structural and biomechanical properties within the limbal niche was demonstrated.

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