Abstract
SoxB, cell cycle and neurogenesis
Highlights
Sox genes encode for a group of transcription factors that share the presence of an HMG-type box
The nervous system arises from primitive neuroepithelial cells that give rise to neural stem cells (NSCs), cells that have the potential to self-renew and differentiate into neurons, astrocytes and oligodendrocytes
Proteins encoded by Sox14 and Sox21 genes are very similar to each other but distinct from those encoded by Sox1-3, in areas outside the HMG domain and Group B homology that lies immediately C-proximal of the HMG domain (Uchikawa et al, 1999)
Summary
Sox genes encode for a group of transcription factors that share the presence of an HMG-type (high mobility group) box. Sox proteins activate or repress target gene transcription, via interactions with a partner factor in a cell-type specific manner (Kondoh and Kamachi, 2010).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
