South-Italy -thalassemia: a novel deletion not removing the -globin silencing element and with 3' breakpoint in a hsRTVL-H element, associated with -thalassemia and high levels of HbF

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Hereditary persistence of fetal hemoglobin (HbF) in adulthood may be due to: mutations in the γ-globin genes promoter, mutations in the transcriptional factors involved in their regulation, polymorphic sequences or large deletions in the β-globin cluster.[1][1] Recently, Sankaran clarified the