Abstract
BackgroundThe monoclonal antibody sotrovimab is manufactured to antagonize many types of coronaviruses including the SARS-CoV-2. It is used mainly to treat mild and moderate COVID-19 infection and to prevent the progression of the disease from critical disease to severe.ObjectivesTo assess the effectiveness of sotrovimab in the early treatment of mild and moderate COVID-19 infections and prevention of disease progression to severe and critical disease.MethodsThis study was performed on 220 outpatients who have already received sotrovimab in Obaidullah Hospital, United Arab Emirates. All patients underwent the following before receiving sotrovimab: routine laboratory studies (CBC, liver function tests, and kidney function tests) and other laboratory tests (C reactive protein (CRP), D dimer, and chest x-ray). All patients received sotrovimab in a dose of 500 mg once intravenous infusion over 30 min. All laboratory studies and CXR are repeated after 1 week of receiving the dose of sotrovimab.ResultsThe outcome was 43 patients deteriorated (19.5%) and 177 patients improved (80.5%). The progress of patients’ symptoms after receiving sotrovimab where the shortness of breath (SOB) deteriorated in 43 patients (19.5%) and improved in 177 patients (80.5%). The cough symptom deteriorated in 43 patients (19.5%), improved in 177 patients (80.5%). The progress of patients' radiology (chest x-ray) where it is deteriorated in 43 patients (19.5%) and improved in 177 patients (80.5%). The rate of hospitalization after receiving sotrovimab where 41 patients were hospitalized (18.6%) and 179 patients were not hospitalized (81.4%). There was a statistically significant difference before and after using sotrovimab in vital signs, inflammatory markers, kidney function tests, electrolytes, endocrine functions, and hepatic profile.ConclusionAmong adults with mild and moderate COVID-19, the use of sotrovimab significantly improved resolution of symptoms, outcome, radiology, or laboratory marker and decreased hospitalization. The findings support using sotrovimab in the early treatment of mild and moderate COVID-19. Wide-scale studies may be required for clarifying the effects of sotrovimab in the treatment of mild and moderate COVID-19 infections.
Highlights
The COVID-19 outbreak has ended the life of more than 3 million people all over the world
Wide-scale studies may be required for clarifying the effects of sotrovimab in the treatment of mild and moderate COVID-19 infections
The study was performed on 220 outpatients who have already received sotrovimab
Summary
The COVID-19 outbreak has ended the life of more than 3 million people all over the world. The monoclonal antibody sotrovimab is manufactured to antagonize many types of coronaviruses including the COVID-19. We hypothesized that a monoclonal antibody that antagonizes all sarbecoviruses would target a highly conserved epitope that would be functionally known as COVID-19 evolves. Supporting this theory, the in vitro sotrovimab remains active against many COVID-19 strains firstly discovered in the UK (B.1.1.7), South Africa (B.1.351), Brazil (P.1), and California (B.1.427/B.1.429) [9]. Monoclonal anti-bodies manufactured for COVID-19 adhere to the receptor-binding element that includes the angiotensin-converting enzyme 2 (ACE2) receptor that characterizes by its mutating and immunological activity [10]. The monoclonal antibody sotrovimab is manufactured to antagonize many types of coronaviruses including the SARS-CoV-2. It is used mainly to treat mild and moderate COVID-19 infection and to prevent the progression of the disease from critical disease to severe
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