Sonothrombolysis of embolic carotid artery, using pesda microbubbles- mediated B-mode ultrasound- guided extracorporeal pulsed low- level focused confocal dual frequency ultrasound accompanied by streptokinase administration

Abstract

Background and Aims: Therapeutic ultrasound was found to selectively lyse thrombi with a wide margin of safety. Ultrasound effects sonothrombolysis by selective disruption of the fibrin matrix of the thrombus. In this study, we developed an experimental sonothrombolysis system, and investigated its effectiveness on carotid artery recanalization, accompanied by intravenous streptokinase and PESDA (perfluorocarbon exposed sonicated dextrose albumin) microbubbles administration, wherein diagnostic ultrasound imaging system is combined with the therapy system, with a goal of increased safety.