Sonochemical Synthesis of Two New Nanostructured La(III) Coordination Polymers: Inducing Tongue Cancer Cell Apoptosis and ROS Accumulation by Targeting FHIT

Abstract

In this research, we represented the structural characterization and preparation of two La(III)-based coordination polymers {[La(TATAB)(H2O)](H2O)2}n (1, H3TATAB = 4,4,4″-s-triazine-1,3,5-triyltri-m-aminobenzoic acid) and {[La(TCA)(H2O)](H2O)4}n (2, H3TCA = 1,3,5-tris (4-carbonylphenyloxy) benzene) by the usage of two flexible tricarboxylate ligand with different donor sites as the joints along with the different functional backbones. Furthermore, the nanostructures of complexes 1 and 2 (denoted as nano 1 and nano 2 hereafter) have been prepared via a sonochemical synthesis approach. The results indicated that nano 1 can block the SCC-25 cancer cells’ proliferation. Moreover, Annexin V-FITC/PI assay was carried out to discover the SCC-25 (Phosphorus cancer cells of human tongue) cancer cells’ apoptosis after compounds treatment. The data showed that nano 1 significantly improve the apoptotic cells numbers rather than nano 2. In addition, nano 1 facilitated the ROS’s (ROS = reactive oxygen species) accumulation which are important in cell apoptosis. The western blot showed that nano 1 induce cell apoptosis via up-regulating FHIT expression.