Abstract
Abstract In this study, we evaluated the performance of nano-γ-Fe2O3–SO3H catalyst in the Biginelli reaction and synthesized 3,4-dihydropyrimidine-2-(1H)-ones. This reaction was carried out under solvent-free and ultrasonic irradiation conditions and belonged to one-pot multicomponent reactions (MCRs) with an adopted aromatic aldehyde, ethyl acetoacetate, and urea as starting materials for the beginning of the reaction. The synthesized materials were efficient in synthesizing 3,4-dihydropyrimidine-2-(1H)-ones via the Biginelli reaction under reaction conditions. Thus, the advantages of using nano-γ-Fe2O3–SO3H in the Biginelli reaction are short reaction time, high efficiency, green method, solvent free, and cost-effective. Furthermore, nano-γ-Fe2O3–SO3H as a heterogeneous catalyst can be recycled five times without significantly reducing catalytic activity.
Highlights
Many studies on nanocatalysts had been performed by researchers. Nanocatalyst research always has been one of the most exciting topics in green chemistry and nanochemistry
In the last decade, many studies on nanocatalysts had been performed by researchers
In recent years, magnetic nanoparticles have attracted the attention of many researchers, and among magnetic nanoparticles, iron nanoparticles are of particular importance [6,18]
Summary
Many studies on nanocatalysts had been performed by researchers. Nanocatalyst research always has been one of the most exciting topics in green chemistry and nanochemistry. This article evaluated the performance of sulfonic acid-functionalized metal oxide nanocatalyst (nano-γ-Fe2O3–SO3H) in the Biginelli reaction, which showed good activity and reusability [34]. Ones in the Biginelli reaction using a nano-γ-Fe2O3–SO3H catalyst under ultrasonic irradiation and solvent-free conditions.
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