Biginelli reaction using lemon juice as catalyst under microwave irradiation

Abstract

Actually, multicomponent reaction (MCR) has been seen target of organic synthetic chemists due your specificity in furnish desired products without side reactions. In 1893, Pietro Biginelli published your pioneer research about a MCR that knowed as Biginelli reactiob. 1 This MCR was carried out in onepot and furnished 5-ethoxycarbonyl-6-methyl-4phenyl-3,4dihydropirimidin-2(1H)-one (DHPM) as only product from reaction between benzaldehyde, ethyl acetoacetate and urea under acid catalysis. Biginelli reaction has been developed in several reaction medium, mainly under microwave irradiation 2 . This reaction has been furnished many compounds with pharmacological activity potentials such as, for example, Monastrol, that can anticancer activity. Many studies shown that DHPMs has been prepared from Biginelli reaction in presence or free-solvent and different catalysts. In this work was realized a methodology for obtention DHPMs via Biginelli reaction under microwave irradiation, lemon juice was used as catalyst.