Abstract
Consumption of deuterium depleted water (DDW) (46 ± 2 ppm) as drinking water by white outbred female rats (20 - 22 months) during five weeks led to the development of a well-pronounced geroprotector effect, which manifested in occurrence of the estrous cycle restoration signs, as well as in the coat state improvement, compared with the same characteristics of animals that received drinking water with a deuterium content of 150 ppm. Besides, rats receiving DDW showed the improvement of the skin bactericidal power. Thus, experiments in mammals provided a direct confirmation of the geroprotector properties of DDW. The current study revealed a deuterium content reduction in blood (according to the NMR (nuclearmagnetic resonance) spectroscopy data) and visceral organs: liver, kidney, and heart (according to the mass spectroscopy data) in animals receiving DDW. A more pronounced decrease in the deuterium content was recorded in the rat blood plasma (33.2%) compared with the deuterium content changes in visceral organs (liver -7.2%, kidney -9.7%, heart -7.3%), which generally led to a change in the direction of the D/H isotopic gradient with consumption of DDW by the animals (CDblood plasma < CDvisceral organs).
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