Abstract
A total number of 38 buffaloes aged between 4-7 years old with body weight ranged between 400-500kg and belonged to private farms in Ismailia Governorate were studied. Twenty of them showed the classical signs of hypophosphataemia while eight buffaloes were proved healthy by both clinical and laboratory investigations used as control group. In addition to the protective group that obtained a dose of drugs containing phosphate e.g. dibasic sod. Phosphate and eat bran in sufficient quantities and constitute Ten buffaloes. Haematological studies revealed marked decrease in erythrocytic count , haemoglobin concentration and packed cell volume in diseased animals. Biochemical analysis of blood sera showed a highly significant hypophosphataemia, hypocalcaemia and hypomagnesemia with significant increase in serum sodium and potassium levels in diseased buffaloes. In diseased Buffaloes, all parameters improved in affected buffaloes after 10 days of treatment with the use of two lines of treatment containing Tonophosphan or dibasic sodium phosphate. The protective group of buffaloes showed non significant changes in all studied parameters and pass the period of incidence of hypophosphataemia without any signs of the disease. So, prevention of hypophosphataemia can be done by giving a dose of drugs containing phosphate, and giving bran ad libidum in a balanced ration containing all necessary minerals and vitamims ,
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