Abstract
SummaryA water extract of desiccated hog stomach acidified to pH 4.5 is active in the treatment of pernicious anemia. The hematopoietically active substance does not pass through the ultra-filter and is stable toward alkali. Stomach extracts inactivated by heat do not regenerate their hematopoietic activity by treatment with pepsin. An acid extract contains 2 factors, one heat-stable and the other heat-labile, both of which are necessary for the production of a reticulocyte response in a patient with pernicious anemia. An acid extract incubated for 8 hours produces a hematopoietically active substance which is soluble in 70% alcohol and which resists a temperature of 60°-65°C. for 30 minutes, but not a boiling temperature. Incubation in this manner produces a substance which is not so heat-stable as the anti-anemic principle in liver but which may be an intermediate product more heat-stable than the original stomach fractions.
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