Some observations on the radiology of Lignac-Fanconi disease and renal infantilism.

Abstract

I Have been interested in the problem of resistant rickets from the time when, in association with the late Sir Leonard Parsons, who was making a study of renal infantilism and coeliac disease, I made an investigation into the radiological appearances in these conditions. I published the result of my work on the radiological appearances in renal infantilism in 1928. My purpose in bringing to your notice the radiological appearances seen in Lignac-Fanconi disease, is that recent work on this condition may well offer an explanation of a problem which has exercised my mind since I made a study of the bone changes in renal infantilism. The Lignac-Fanconi disease is so-called after the two authors who first gave a comprehensive description of the condition. It is a disease of infancy and childhood; our oldest patient has not survived beyond the age of 14 years. I wish to make it clear at the outset that it is not synonymous with what in these days is often loosely referred to as the “Fanconi syndrome” found in...