Abstract
The effects of garded doses of phentolamine on gastric secretion, gastric emptying rate, gastric mucosal mucus content and gastric musocal lseion incidence were studied in conscious rats 2 h after intramuscular administration. In pylorus-occluded rats, phentolamine (5, 10 or 20 mg/kg) produced dose-dependent decreases in the gastric secretory volume and total acid output. Similar doses of the drug also procued dose-dependent decreases in the gastric emptying rate in animals without pylorus occlusion (intact rats), but did not affect the gastric mucosal mucus content. The incidence of gastric mucosal lesions in pylorus-occluded or intact animals rose with increasing doses. The finding are discussed in the light of the possibility that phentolamine, in the dose range examined, possesses a sympathomimetic action which would underline the gastric lesions observed.
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