Abstract
The present study was carried out to evaluate the gastric antisecretory and antiulcer activities of 'Cinnamon' Cinnamomum zeylanicum in rats. The aqueous suspension of cinnamon (250 and 500 mg/kg) has been screened using pylorus ligation (Shay) rat model, necrotizing agents and indomethacin-induced ulceration in rats. Histopathological assessment was done on gastric tissue of rats. Gastric wall mucus and nonprotein-sulfhydryl contents were also estimated. Cinnamon suspension pretreatment decreased the basal gastric acid secretion volume and rumenal ulceration in pylorus ligated rats. The suspension effectively inhibited gastric hemorrhagic lesions induced by 80% ethanol, 0.2 M sodium hydroxide, and 25% sodium chloride. The cinnamon suspension also showed antiulcer activity against indomethacin. Pretreatment with cinnamon suspension offered a dose-dependent protection against various histological indices. Treatment of rats with cinnamon replenished the ethanol-induced decreased levels of gastric wall mucus and nonprotein-sulfhydryl concentrations. The gastroprotection of cinnamon observed in the present study is attributed to its effect through inhibition of basal gastric secretion (attenuation of aggressive factors) and stimulation mucus secretion (potentiation of defensive factors); and increase in nonprotein-sulfhydryl concentration probably due to prostaglandin-inducing abilities mediated through its antioxidant property. Key words: Cinnamon, Cinnamomum zeylanicum, gastric secretion, antiulcer, histopathological changes.
Highlights
‘Cinnamon’, Cinnamomum zeylanicum Nees (Lauracea), locally known as Qerfah or Darsin is an ancient and important spice with wide applications in flavoring, perfumery, beverages and medicines (Jayaprakasha et al, 2003)
Cinnamon bark is an important component of some Japanese herbal compounds, which have been reported to possess an antiulcer activity (Osawa et al, 2002)
Aqueous suspension of cinnamon showed a significant decrease in basal gastric acid secretion and ulcer protective effects in different experimental models with different etiopathogenesis of ulceration
Summary
‘Cinnamon’, Cinnamomum zeylanicum Nees (Lauracea), locally known as Qerfah or Darsin is an ancient and important spice with wide applications in flavoring, perfumery, beverages and medicines (Jayaprakasha et al, 2003). Cinnamon bark is an important component of some Japanese herbal compounds, which have been reported to possess an antiulcer activity (Osawa et al, 2002). An antibacterial effect of cinnamon ethanolic and aqueous extracts against Helicobacter pylori has been reported (Nostro et al, 2005). The essential oil of cinnamon is known to have antibacterial (Jirovetz et al, 2002), antifungal (Misra et al, 2000), ovicidal and antiparasitic activities (Young-Cheol et al, 2005). Since there are no scientific reports available in the existing literature on antiulcer effect aqueous suspension of cinnamon (ASC) (a common dosage form among Unani and Arab traditional medicine). The present study was undertaken to investigate anti-secretagogue and antiulcer activities of an aqueous suspension of cinnamon in-vivo test models in rats
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