Abstract
Seven new esters of gentisic acid were subjected to four selected pharmacological testing procedures: acute toxicity, antispasmodic activity, local anesthetic activity, and anticonvulsant activity. All of the seven new esters were more toxic than the parent, gentisic acid, when given intraperitoneally in mice in a soluble form. Of the four esters with amino alcohols, only 2-diethylaminoethyl-5-ethoxy salicylate hydro-chloride possessed antispasmodic or local anesthetic activity. None of the four esters of gentisic acid tested for anticonvulsant activity possessed this activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have