Abstract
In this study, some neuropharmacological effects of methnolic root extractof Cissus quadrangularis Linn. (CQ) belongs to family Vitaceae werestudied in mice using various models. The CQ root extract significantlyinhibited acetic acid-induced writhings and increased tail flick withdrawalresponse in mice. The effects of CQ on CNS were studied by using,spontaneous motor activity, exploratory behaviour, rota-rod performanceand potentiation of pentobarbitone sleeping time in mice. Preliminaryphytochemical evaluation and acute toxicity values were also carried outand LD50 was found to be 1000 mg/kg by i p route. The extract (50,100and 200 mg/kg i. p.) produced reduction in spontaneous motor activity,exploratory behaviour and motor coordination and prolongedpentobarbitone sleeping time. Preliminary qualitative chemical studiesindicated the presence of triterpenoids, flovonols, sapononis, and alkaloidsin the extract. The results suggest that the methanolic root extract of CQcontains some active principles, which may be sedative in nature. (Afr. J.Biomed. Res. 9:69 – 75, May 2006) Keywords: Cissus quadrangularis; Sedation; Spontaneous motor activity, ExploratoryBehaviour, Motor coordination, Pentobarbital sleeping time
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