Abstract
Background: The plant Pentapetes phoenicea was traditionally used to treat central nervous system disorders. The present study was conducted to evaluate the neuropharmacology of the plant using various methods involving rats and mice. Objective: The study probes the neuropharmacological activities of P. phoenicea in rats and mice. Materials and Methods: The effect of the extracts on pentobarbitone-induced sleeping time, different models of seizures, spontaneous motor activity, exploratory behavior, and motor co-ordination were evaluated. Results: The extracts elicited significant prolongation of pentobarbitone-induced sleeping time, reduction in spontaneous motor activity, and exploratory behavior. The extracts prolonged the onset of seizures. Significant muscle relaxation was expressed in extract treated groups. Gamma-aminobutyric acid (GABA) levels were elevated in rats pretreated with P. phoenicea. Reversed-phase high-performance liquid chromatography was performed to rutin isolated from a methanolic extract of P. phoenicea. Conclusion: The results confirmed that P. phoenicea possesses significant anxiolytic potential with sedative action, and the mechanism underlying involves GABAnergic activity.
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