Abstract
Thorn and harrop (1) have shown that the administration of testosterone to normal dogs is followed by a decreased excretion of sodium and water, an effect resembling that of adrenal cortical extract. Kochakian and Murlin (2) found the nitrogen content of urine in castrate dogs diminished after the injection of androgens, while Thorn and Engel (3) noted a decrease in urinary nitrogen in normal dogs given testosterone propionate. These reports represent but a few of the recorded observations on animals. More recently, Kenyon et al. (4) have shown that in normal men and women, and particularly in eunuchoids, the injection of testosterone propionate ‘produced a reduction in the urinary excretion of nitrogen, sodium, potassium and chloride.’ When the injections of testosterone were discontinued, the excretion rates returned to the pre-injection levels. Jones et al. (5) noted that the oral administration of methyl testosterone possessed ‘the property of causing nitrogen, electrolyte and water retention.’
Published Version
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