Some key issues in immunologica; surveillance and its clinical application

Abstract

Immunological surveillance, analysis including cells to biological is one of the important components in clinical laboratory immunology. This paper focuses on three issues. First of all is the measurement of antigen-specific T cell, which is very important for understanding the pathogenesis of immunological related diseases because of the central role played by T cell in immune response. It is optional to adopt different assays according to different facilities and puroposes such as flow cytometer or the number or function of T cells. Secondly, it is no doubt that positive autoantibodies are key bio-markera in the diagnosis of autoimmune diseases. And what is more autoantibodies could predict the occurrence of certain autoimmune diseases. More and more researches showed that autoantibodies could be detected in patients with tumors, which help for either diagnosis of tumors or screening of therapeutic target markers. Finally, the application of cytokine measurement is discussed. Clarification of cytokine profiles is the way to understanding pathogenesis of immunological related diseases, it is also in favor of monitoring severity of the diseases, But there are shortages concerning organ or tissue specific, as well as good quality control. Key words: T-lymphocytes; Immunoassays; Autoantibody profile