Abstract
Interleukin-35 (IL-35) is a newly identified inhibitory cytokine of IL-12 family. In a variety of immune responses mediated by T and B cells, IL-35 has been proved to play a vital role of immunological regulation. IL-35 further contributes to the propagation of immune tolerance, which is crucial for maintenance of immune balance and restriction of inflammatory injuries. Heretofore, no pro-inflammatory effects of IL-35 have been discovered. Recent basic and clinical studies on inflammatory and autoimmune diseases have revealed the pathophysiological significance of IL-35 and its significant impact on the occurrence, development and prognosis of diseases. IL-35 is expected to become an important immunological marker for the diagnosis, monitoring and prognosis of inflammatory and autoimmune diseases, as well as a potential target for regulation and treatment. The in-depth study of IL-35 expression and regulation will provide new ideas and directions for clinical diagnosis and treatment of inflammatory and autoimmune diseases. Key words: Interleukin-35; Inflammatory disease; Autoimmune disease; Immunological effect; Diagnosis; Surveillance
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