Abstract
The influence of thyroid hormones on the pituitary-adrenal axis in rats was investigated using the following parameters: 1) plasma corticosteroid levels; 2) production of A4-3-ketosteroids by adrenal fragments in vitro; 3) pituitary ACTH content; 4) volume of distribution of injected corticosterone; 5) adrenal weight. Mild hyper thy roidism was induced by adding thyroglobulin to the diet. Hypothyroidism was induced by goitrogen administration, by thyroidectomy, or by hypophysectomy to permit segregation of extrahypophysial and extrathyroidal effects. Hyperthyroidism induced an increase in adrenal weight, which could be prevented by injection of prednisolone tertiarybutylacetate or by hypophysectomy. Plasma corticosteroid levels were significantly higher in thyroid-treated animals (intact or thyroidectomized) than in controls, following ACTH injection. However, this increase was attributable to a 50% reduction in the volume of distribution of corticosterone in thyroidtreated animals. Adrenals of hyperthyro...
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