Effect of amphenone on gastric secretory activity.

Abstract

A single subcutaneous injection of amphenone to pyloric ligated rats produced a significant decrease in gastric secretory volume, free acid and potassium content, with an increase in pH, gastric juice sodium and pepsin concentration. Cortisone, corticosterone, DCA or ACTH administered with amphenone did not alter the amphenone effect. Aldosterone alone produced a reduction in gastric juice sodium. When amphenone was injected with aldosterone, the amphenone effects, including an increased sodium, were again observed. When amphenone was administered with histamine, the amphenone effects relating to pH and free acid concentration were not observed. Adrenalectomy produced a decrease in gastric secretory volume, acidity and pepsin secretion, and an increase in sodium and pH. In previously adrenalectomized rats the amphenone inhibitory effects on gastric secretion were absent. An increase in adrenal gland weight was observed 4 hours after amphenone administration, but was not seen when cortisone, corticosterone, DCA, aldosterone or histamine were administered with amphenone. ACTH alone or with amphenone produced an increase in adrenal weight. Amphenone caused a considerable increase in thymus weight, which could be prevented by the simultaneous injection of corticosterone, aldosterone or histamine, but not by DCA or adrenalectomy. ACTH or cortisone alone or in combination with amphenone decreased thymus weight.