Year-end Sale % OFF 
Abstract
AbstractEight common tablet disintegrants (Amberlite IRP-88, Corn Starch U.S.P. CLD, Explotab, Ac-Di-Sol, Sta-RX 1500 Starch, Polyplasdone XL, and Guar Gum) were used in concentrations of 0, 0.25, 0.5, 1 and 2% (w/w) in a direct compression system of 75:25 Unmilled Calcium Phosphate Dihydrate/Anhydrous Lactose. Using a Recording Powder Flowmeter (RPF) it was noticed that linearity of flow was relatively unaffected while g/sec. flow rate decreased with increasing concentrations. Each system was then lubricated and tableted keeping the applied pressure relatively constant. Evaluation of the resulting tablets showed that even at very low disintegrant concentrations, significant reduction in disintegration time took place. At the same time, very few detrimental effects often seen with tablet disintegrants, were noticed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
