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Abstract
AbstractThe disintegrant actions of croscarmellose type A (Ac-Di-Sol, FMC Corp.) and croscarmellose type B (CLD-2, Buckeye Cellulose Corp.) have been compared to that of corn starch in direct compression tablets in which microcrystalline cellulose (Avicel PH101, FMC Corp.) was the matrix. Two types of formulations were examined using either pyridoxine or hydrochlorothiazide as drug. The data clearly shows that both forns of croscarmellose are markedly superior to corn starch and are active at quite low concentrations. The CLD-2 may promote more rapid dissolution in some systems than Ac-Di-Sol.
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