Abstract

IN A RECENT PUBLICATION we compared the effects (1) in the immature castrate macaque following subcutaneous injections of testosterone propionate (perandren) with those following implantations of crystalline testosterone. It was found under the experimental conditions used that testosterone in the form of crystalline pellets produced a greater relative increase in weight in the accessory genitalia tissue. In those experiments the increase in weight of the accessory genitalia was used as a criterion to compare the effectiveness of administering testosterone by the two methods. It was also noted that the histologic changes following pellet implantation were identical with those following injections. Our experiments indicated that in the primate implantations of testosterone in the form of crystals was a more efficient and physiological method than that of injecting testosterone propionate in oil at intervals of 2 or 3 times per week.

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