Abstract
Expression changes of somatostatin receptor subtypes (SSTRs) including SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5 in the development of gallbladder cancer were assessed with attention to relationships with clinical pathological characteristics. SSTRs in 29 gallbladder cancer and 25 normal gallbladder tissue specimens were examined by immunohistochemical staining. Differences between SSTRs expressions and clinical pathological parameters were analyzed by chi-square test. The five subtypes of SSTR were all expressed in gallbladder cancer tissues and SSTR3 presented the highest expression. SSTR5 expression was increased significantly in gallbladder cancer (P<0.05) compared with that in normal gallbladder tissue. SSTR3 expression in highly and moderately differentiated gallbladder cancer was significantly higher than that in poorly differentiated lesions (P<0.05). SSTR4 expression was lower in gallbladder cancer with lymph node metastasis than that in gallbladder cancer without lymph node metastasis (P<0.05). Therfore, these results indicated that SSRT5, SSTR3 and SSTR4 may play important roles in the formation and development of gallbladder cancer.
Highlights
Gallbladder cancer, as a frequent cancer existing in alimentary canal, threatens human health these years
Expressions of somatostain receptor (SSTR) in normal gallbladder tissue and gallbladder cancer tissue Immunoreactivity of investigated gallbladder tissues was estimated in pathologically altered cells of gallbladder cancers and normal gallbladder tissues
Five subtypes of SSTR were all expressed in gallbladder cancer tissues and the brown-yellow particles mainly distributed in the cytoplasm and on cytomembrane (Figure 1)
Summary
Gallbladder cancer, as a frequent cancer existing in alimentary canal, threatens human health these years. Somatostatin (SST), as a kind of growth hormone releasing inhibiting hormone, is engaged in regulation of hormones secretion in different ways and formation of gallbladder cancer (Pisarek et al, 2009). SST has two kinds of molecular forms: 14 peptide somatropin (SS214) and 28 peptide somatrpin (SS228), which have the similar structure and bioactivity including inhibition the function of endocrine and exocrine cells, regulation the movement of biliary tract and gastrointestinal tract, adjustment the recognition function of brain as neuromediator (Reubi et al, 1997; Hofsli, 2002). Somatostatin receptor (SSTR), as a G protein coupled receptor, formed by seven specific transmembrane segments and expressed in multiple human primary tumors (Hall, et al, 2002). Our research designed to investigate the expressions of the five SSTR subtypes in human primary gallbladder carcinoma tissue by immunohistochemisty (IHC). We suppose to find the relationship between the SSTRs and gallbladder cancer in clinical pathology characteristics, which could provide certain supports for diagnosis, therapy and prognosis of gallbladder cancer
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