Abstract
Somatic Genomic Mosaicism in Multiple Myeloma.
Highlights
Somatic genomic mosaicism occurs when somatic cells of the body display different genotypes (Table 1), it has recently received increased attention because of its implications in disease, including neurodegenerative diseases and Down syndrome (Iourov et al, 2008, 2010, 2019; Biesecker and Spinner, 2013; Hultén et al, 2013; Vijg, 2014; Campbell et al, 2015; Fernández et al, 2016)
Genomic mosaicism contributes to high levels of cellular heterogeneity in pathological conditions, which is a distinguishing feature of cancer (Heng, 2015, 2019)
High heterogeneity in cancer represents an extreme example of genomic mosaicism
Summary
Keywords: cellular heterogeneity, fuzzy inheritance, genome chaos, genome theory, macro-cellular evolution, two phases of cancer evolution, karyotype coding, system inheritance Edited by: Obul Reddy Bandapalli, Hopp Children’s Cancer Center Heidelberg (KiTZ), Germany Reviewed by: Ezhilarasi Chendamarai, Washington University in St. Louis, United States Hamid Mahmoudpour, Johannes Gutenberg University
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