Abstract
Solving the mystery of “leaky” membranes
Highlights
Agre was trained as a blood specialist, and, in 1988, had a small laboratory at Johns Hopkins University (JHU) that studied red cell membrane proteins, hoping to identify the D antigen of the Rh blood group
They had no idea that this protein was the water channel
Eric Fearon at the University of Michigan Rogel Cancer Center nominated this paper as a Classic
Summary
Agre was trained as a blood specialist, and, in 1988, had a small laboratory at Johns Hopkins University (JHU) that studied red cell membrane proteins, hoping to identify the D antigen of the Rh blood group. They had no idea that this protein was the water channel. “It took a bit of confidence building to assess that, it was a new protein,” Agre says.
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