Solving Problems with NMR Spectroscopy

Abstract

The Basics of Modern NMR Spectroscopy:What is NMR? Instrumentation. Creating NMR Signals. Spin-Echo and Polarization Transfer: Spin-Echo Formation in Homonuclear and Heteronuclear Systems. Cross-Polarization. Polarization Transfer in Reverse. The Second Dimension: Data Acquisition in 2D NMR. Data Processing in 2D NMR. Plotting 2D Spectra. Nuclear Overhauser Effect: nOe and Selective Population Transfer. Relaxation. Mechanism of nOe. Factors Affecting nOe. Some Practical Hints. Important 2D NMR Experiments: Homo- and Heteronuclear J-Resolved Spectroscopy. Homonuclear and Heteronuclear Shift-Correlation Spectroscopy. Two-Dimensional Nuclear Overhauser Spectroscopy. Two-Dimensional Chemical Exchange Spectroscopy. Homonuclear Hartmann-Hahn Spectroscopy (HOHAHA), or Total Correlation Spectroscopy (TOCSY). Inverse NMR Spectroscopy. Inadequate. The Third Dimension: Basic Philosophy. Types and Positions of Peaks in 3D Spectra. Recent Developments in NMR Spectroscopy: Selective Pulses in Modern NMR Spectroscopy. One-Dimensional Experiments Using Soft Pulses. Heteronuclear Selective 1D NMR Experiments. Two-Dimensional Experiments Using Soft Pulses. Soft Excitation in Two Dimensions. Three-Dimensional Experiments Using Soft Pulses. Field Gradients. Logical Protocol for Solving Complex Structural Problems: 3-Hydroxylupanine. (1). (+)-Buxalongifolamidine. (2). References. Subject Index.