Solvent-free synthesis of 2H-pyrans: One-pot reactions of dithiocarbamates, alkyl propiolates, and isocyanides

Abstract

A novel, convenient, and an efficient approach to the synthesis of 2H-pyrans has been reported based on the multicomponent reaction. Solvent-free condition for the reaction of dithiocarbamates, alkyl propiolates and isocyanides lead to the formation of 2H-pyrans in good yields. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without using any catalyst. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods. J. Heterocyclic Chem., lpar;2011).