Abstract
In this work new isoquinazoline derivatives were synthesized in excellent yields using three component reactions of isoquinoline or its derivatives, isothiocyanates, and 1-(6-amino-2-(prop-1-en-2-yl)benzofuran-5-yl)ethan-1-one in the presence of triethylamine (Et3N) under solvent-free conditions at room temperature. Also, the antioxidant activity of some synthesized isoquinazoline was studied using trapping of radical by DPPH and ferric reduction activity potential (FRAP) experiment. The short time of reaction, high yields of products, easy separation of products are some benefits of this procedure.
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