Abstract
A previous model for the understanding and prediction of solvent strength as a function of mobile phase composition has been applied to recent data from the literature and further tested in terms of data reported here. On the basis of this study, we can now predict solvent strength (silica as adsorbent) for a broader range of mobile phase mistures than previously, and the accuracy of the model has been further improved by recognition of two kinds of solvent delocalization: (a) restrictedaccess delocalization and (b) site-competition delocalization. Mixtures of alcohols behave normally so that the strength of such mobile phases can be predicted with adequate accuracy. This was not the case for alumina as adsorbent. This and other differences between silica and alumina as regards mobile phase effects can be rationalized in terms of differences in their surface structures.
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