Solvation behaviour of an antihelmintic drug in aqueous solutions of sodium chloride and glucose at different temperatures

Abstract

The experimental values of densities (ρ), speeds of sound (u) and relative viscosities (ηr) of piperazine citrate in aqueous solution and in 0.06mol·kg−1 of sodium chloride and d-glucose as a function of concentration have been obtained at T/K=(293.15, 303.15 and 313.15). The thermodynamic parameters such as apparent molar volume (Vϕ) of solute, isentropic compressibility (κs), apparent molar isentropic compressibility (κϕ) of solute, piperazine citrate in water and in aqueous solutions of sodium chloride and d-glucose have been computed using the density and speed of sound data. The limiting apparent molar volume of solute (Vϕ0), limiting apparent molar compressibility (κϕ0) in binary and ternary solution have been obtained using apparent molar volume and apparent molar compressibility data. The limiting apparent molar expansivity (Eϕ0) of solute and thermal expansion coefficient (α∗) in both aqueous binary and ternary solutions has been computed. Transfer volumes (ΔtrVϕ0) and transfer compressibilities (Δtrκϕ0) of piperazine citrate from water to aqueous solutions of sodium chloride and d-glucose at different temperatures have been obtained. The Jones-Dole viscosity coefficients A, B, D, variation of viscosity B coefficient with temperature i.e. dB/dT, hydration number for aqueous solutions of piperazine citrate and in aqueous solutions of sodium chloride and d-glucose have been determined. The above parameters have been used to throw light on the various interactions occurring between binary and ternary systems.