Solution-phase parallel synthesis using ion-exchange resins

Abstract

Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. Several compound libraries have been prepared using the basic ion-exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries will be reviewed. Acidic and basic ion-exchange resins are useful reagents in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins, and acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. The utility of ion-exchange resins as a means of generating focused libraries will be discussed.