Solution thermodynamics of azlocillin sodium in four pure solvents and three binary solvent mixtures

Abstract

In this study, the solubility of azlocillin sodium in four pure solvents and three binary solvent systems was measured at temperature from 278.15 to 313.15 K by using a gravimetric method. The results indicated that the solubility of azlocillin sodium in all the selected pure and binary solvent systems increased with the rising of temperature. In methanol + (1-propanol, acetone or acetonitrile), it decreases with the increase of the initial molar fraction of 1-propanol or acetone or acetonitrile. The experimental data were correlated by the modified Apelblat equation, the CNIBS/R-K model, and the combined version of the Jouyban-Acree and the modified Apelblat model. The calculation results agreed fairly well with the experimental data. Furthermore, the thermodynamic properties of mixing of azlocillin sodium in different mixtures were obtained based on the NRTL model.