Abstract
In this work, solution thermodynamic properties including solubility, mixing thermodynamic properties and dissolution thermodynamic properties are investigated in detail. Gravimetric method was utilized for measuring the solubility data of flurbiprofen in twelve pure solvents including n-propanol, isopropanol, n-butanol, isobutanol, isopentanol, isopropyl acetate, methyl tert-butyl ether, isopropyl ether, acetonitrile, n-octane, n-heptane and n-hexane over the temperatures range from 283.15 to 323.15 K under atmospheric pressure. The results indicated that the solubility of flurbiprofen increased with the increasing temperature. Furthermore, the experimental solubility data were correlated by the modified Apelblat equation, λh equation, Wilson model and NRTL model. And the modified Apelblat equation can give better correlation results with lower values of ARD%. Moreover, mixing and dissolution thermodynamic properties of flurbiprofen in different solvents were calculated according to the experimental data and the NRTL model.
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