Abstract
AbstractRapid parallel liquid‐phase synthesis of pyrazoles has first been developed. The 1,3‐dipolar cycloaddition between nitrilimines generated in situ and soluble polymer‐supported alkynyl or alkenyl dipolarophiles in parallel one‐pot fashion gave the corresponding PEG‐supported regioisomeric pyrazoles or regiospecific pyrazolines. The latter was assuredly oxidated by DDQ to PEG‐supported regiospecific pyrazoles. Cleavage from the support under mild conditions afforded pyrazoles in good yields and high purity.
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