Abstract
The generalized Shwartzman reaction (GSR) was induced in rabbits. Blood samples were obtained at intervals and determinations were made of fibrinogen concentration, platelet count, soluble fibrin monomer complexes (SFMC) and the fibrinolytic activity of the euglobulin fraction. In addition, the tissue plasminogen activator activity in kidney sections was measured. An increase in SFMC and decrease in tissue activator activity in the outer medullary zone of the kidney were observed 6 hours after the preparative endotoxin dose as well as 3 and 6 hours after the provocative injection. The maximal fibrin deposition within the kidney glomeruli was observed 6 hours after the provocative endotoxin injection and 18 hours later the amount of intraglomerular fibrin decreased but the secondary, necrotic changes of the kidney cortex progressed. The fibrinolytic activity in the outer medullary zone of kidney returned to the normal values at the same time. The importance of the fibrinolytic activity in kidney as a defensive mechanism in GSR is discussed.
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