Abstract
The present study tested the hypothesis that inhibition of soluble epoxide hydrolase (sEH), that increases the level of epoxyeicosatrienoic acids, would attenuate the development of renovascular hypertension in 2K1C rats. Renovascular hypertension was induced by placing a silver clip on the left renal artery in Wistar rats for 25 days. The sEH inhibitor, c‐AUCB was given in drinking water (0.5 mg/day) starting 48 hours before the renal artery clipping. Blood pressure (BP) was monitored by radiotelemetry in conscious animals during 30 days of experimental period. At the end of the experiment the ratio of left heart ventricular weight (mg) to tibial length (mm) (LVW/TL) was used for assessing cardiac hypertrophy.After 30 days of experimental period, systolic BP was not different in sham operated rats treated with sEH inhibitor (106±2 to 104±3 mmHg; n=5) compared to sham control group (107±3 to 112±4 mmHg; n=4). However, the sEH inhibitor, c‐AUCB, attenuated the development of hypertension in treated 2K1C rats (110±2 to 138±3 mmHg, p<0.05; n=5) compared to untreated 2K1C (113±4 to 161±7 mmHg, p<0.05; n=6). Moreover, significantly higher LVW/TL ratio in untreated 2K1C compared to sham control group (26±1 vs. 20±1) was partially attenuated in 2K1C rats treated with sEH inhibitor (23±1, p<0.05).These data demonstrate that sEH inhibition attenuates the development of renovascular hypertension.
Published Version
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