Abstract
Computer simulation was used to demonstrate the formation of complexes between calcium cations and calcium succinate (CS) with sorbitol in an aqueous environment. Solubility-associated descriptors of complexes were calculated, i.e., the enthalpies of complex formation and hydration and log P. Experimental data supported the theoretical calculations in terms of measurements of the solubility of calcium succinate, citrate, and malate in solutions of sorbitol at different concentrations. Aqueous sorbitol was shown to have a solubilizing action in relation to these salts. These results allowed development of a pediatric syrup containing CS in a combined sorbitol-fructose base.
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