Abstract
Mesalazine solubility is important to study in solvent mixtures for chemical and pharmaceutical engineering. Therefore, solubility of the drug was determined in water/1-propanol mixtures at T = (293.2 to 313.2) K. To represent the solid-liquid equilibrium for these systems, the van't Hoff, Apelblat, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), modified Wilson, Jouyban-Acree, Jouyban-Acree-van't Hoff, Wilson, NRTL and UNIQUAC models were employed. The thermodynamic quantities of dissolution and mixing were calculated for mesalazine in aqueous 1-propanol solutions at harmonic temperature. Further, calculations of inverse Kirkwood-Buff integrals show that this drug is preferentially solvated by water in all the mixtures, with exception of x1 = 0.20, at 298.2 K.
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