Solubility of celecoxib in 1-propanol + water mixtures at T= (293.2–313.2) K: experimental data and thermodynamic analysis

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ABSTRACTThe molar solubility of celecoxib (CXB) was measured in the binary mixtures of 1-propanol + water at temperatures ranging from 293.2 to 313.2 K. The obtained solubility data are mathematically represented by employing five cosolvency models (i.e. van’t Hoff equation, Yalkowsky–Roseman model, Jouyban–Acree model, Jouyban–Acree–van’t Hoff model and the modified Wilson model), and the mean relative deviations (MRD%) calculated for the back-calculated solubility data were 2.5%, 68.7%, 12.7%, 12.8% and 20.5%, respectively, for each investigated cosolvency model. The apparent dissolution enthalpy, entropy and Gibbs energy of CXB in these solvent mixtures were also computed based on the van’t Hoff and Gibbs equations.